Probiotics to prevent mental disorders

Year: 2016

Journal: Agro FOOD Industry Hi Tech

Authors: Elsbeth Pekelharing, Geline Ornel


Increased intestinal permeability has been associated with a diversity of gastro-intestinal diseases. Moreover, the intestinal barrier is involved in the bidirectional communication between the GI-tract and the central nervous system. Research has shown that probiotics can positively influence the gut microbiota and intestinal barrier function. The aim of this article is to summarize the research performed with the probiotic formulation (Ecologic® Barrier) that has been specifically developed to strengthen the intestinal barrier function and by this alleviate or prevent mental disorders. In rodent studies this formulation has demonstrated to reduce depressive-like behavior, and in human studies to decrease sensitivity to depression and migraine frequency. This and other research will further unravel the working mechanisms of probiotics on the gut-brain axis and could reveal a potential for a broader range of gut-brain related disorders.