Next Generation Probiotics for Butyrate Production in the Gut


Eva M Gómez del Pulgar, Eleni Tsompanidou, Hermie JM Harmsen




EC Nutrition


Health beneficial effects of Short Chain Fatty Acids (SCFAs) produced in the gut, especially butyrate, and their decreased abundance in several gut-related disorders makes them a potent approach for disease management and prevention. New insights into the microbiome have enlightened the path for new probiotic formulations based on the combined actions (cross feeding interactions) of different human gut commensals to increase SCFAs concentrations in the colon. In this line, the Novobiome consortium was created in order to overcome technical and regulatory challenges to bring these next-generation probiotics (NGPs) to the market to complete the suite of probiotic products for supporting a healthy gut microbiome.