Multispecies probiotic affects fecal short-chain fatty acids in postmenopausal women with obesity: A post hoc analysis of a randomized, double-blind, placebo-controlled study


Igor Łoniewski M.D., Ph.D. a b, Monika Szulińska M.D., Ph.D. c, Mariusz Kaczmarczyk M.D., Ph.D. d, Konrad Podsiadło M.Sc. e, Daniel Styburski Ph.D. d, Karolina Skonieczna-Żydecka Ph.D. a, Paweł Bogdański M.D. c






An increase in three SCFA fecal concentrations in the HPD group was observed: acetic acid (C2; effect [E] = 1.72, SE = 0.73; 95% confidence interval [CI], 0.28–3.16; P = 0.019), butyric acid (C4; E = 0.98, SE = 0.46; 95% CI, 0.08–1.88; P = 0.033), and valeric acid (C5; E = 0.68, SE = 0.23; 95% CI, 0.23–1.12; P = 0.003). The mediation analysis showed that the decrease in uric acid under HPD may be transmitted through the elevation of C5 content. Multi-strain probiotic increases the SCFA content in the stool in a dose-dependent manner, which may diminish some cardiovascular risk factors because of a reduction in blood uric acid levels.